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    products/primary-antibodies/ucp4-antibody-ab183886.pdf

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Signal Transduction Metabolism Energy Metabolism
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Anti-UCP4 antibody (ab183886)

  • Datasheet
  • SDS
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Western blot - Anti-UCP4 antibody (ab183886)

    Key features and details

    • Rabbit polyclonal to UCP4
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-UCP4 antibody
    • Description

      Rabbit polyclonal to UCP4
    • Host species

      Rabbit
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Recombinant fragment within Human UCP4 aa 13-174. The exact sequence is proprietary.
      Database link: O95847

    • Positive control

      • SK-N-SH, IMR32 and SK-NAS whole cell lysates.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.00
      Preservative: 0.01% Thimerosal (merthiolate)
      Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Metabolism
      • Energy Metabolism
      • Signal Transduction
      • Metabolism
      • Mitochondrial
      • Metabolism
      • Pathways and Processes
      • Mitochondrial Metabolism
      • Mitochondrial markers
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Energy transfer pathways
      • Energy Metabolism

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • SK-N-SH whole cell lysate (ab3956)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab183886 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 36 kDa.
    Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 36 kDa.

    Target

    • Function

      UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.
    • Tissue specificity

      Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.
    • Sequence similarities

      Belongs to the mitochondrial carrier (TC 2.A.29) family.
      Contains 3 Solcar repeats.
    • Cellular localization

      Mitochondrion inner membrane.
    • Target information above from: UniProt accession O95847 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 9481 Human
      • SwissProt: O95847 Human
      • Unigene: 40510 Human
      • Alternative names

        • Mitochondrial uncoupling protein 4 antibody
        • SLC25A27 antibody
        • Solute carrier family 25 member 27 antibody
        • UCP 4 antibody
        • UCP4_HUMAN antibody
        • Uncoupling protein 4 antibody
        see all

      Images

      • Western blot - Anti-UCP4 antibody (ab183886)
        Western blot - Anti-UCP4 antibody (ab183886)
        All lanes : Anti-UCP4 antibody (ab183886) at 1/1000 dilution

        Lane 1 : SK-N-SH whole cell lysate
        Lane 2 : IMR32 whole cell lysate
        Lane 3 : SK-N-AS whole cell lysate

        Lysates/proteins at 30 µg per lane.

        Predicted band size: 36 kDa



        12% SDS PAGE

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab183886? Please let us know so that we can cite the reference in this datasheet.

      ab183886 has not yet been referenced specifically in any publications.

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