Human FLASH peptide (ab8455)
Key features and details
- Suitable for: Blocking, WB
Description
-
Product name
Human FLASH peptide -
Animal free
No -
Nature
Synthetic -
-
Species
Human -
Sequence
SERFQQLMKLFEKSKC Amino acids 1253 to 1268 of human FLASH (1). -
Amino acids
1966 to 1981
-
Associated products
-
Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab8455 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
Blocking - Blocking peptide for Anti-FLASH antibody (ab8420)
Western blot
-
Form
Liquid -
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 0.1% BSA
General Info
-
Alternative names
- AA387232
- C8AP2_HUMAN
- CASP 8 associated protein 2
see all -
Function
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cytoplasm. Nucleus. Localizes to discrete nuclear foci. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
Datasheet download
References (0)
ab8455 has not yet been referenced specifically in any publications.
