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    products/proteins-peptides/recombinant-human-akap13p47-protein-ab127097.pdf

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Signal Transduction Protein Phosphorylation Ser / Thr Kinases PKA
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Recombinant Human AKAP13/p47 protein (ab127097)

  • Datasheet
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Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Tags: His-DHFR tag N-Terminus
  • Suitable for: SDS-PAGE

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Description

  • Product name

    Recombinant Human AKAP13/p47 protein
  • Purity

    > 95 % SDS-PAGE.
    Purified via His tag
  • Expression system

    Escherichia coli
  • Accession

    Q12802
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      18 kDa
    • Amino acids

      2 to 161
    • Tags

      His-DHFR tag N-Terminus

Associated products

  • Related Products

    • Anti-6X His tag® antibody [HIS.H8] (ab18184)
    • Anti-6X His tag® antibody [4D11] (ab5000)

Specifications

Our Abpromise guarantee covers the use of ab127097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilized
  • Additional notes

     This product was previously labelled as AKAP13

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • A kinase (PRKA) anchor protein 13
    • A kinase anchor protein 13
    • A kinase anchoring protein
    • A-kinase anchor protein 13
    • AKAP 13
    • AKAP Lbc
    • AKAP-13
    • AKAP-Lbc
    • AKAP13
    • AKP13_HUMAN
    • ARHGEF13
    • Breast cancer nuclear receptor binding auxiliary protein
    • Breast cancer nuclear receptor-binding auxiliary protein
    • BRX
    • c lbc
    • FLJ11952
    • FLJ43341
    • Guanine nucleotide exchange factor Lbc
    • HA 3
    • HA3
    • Ht 31
    • Ht31
    • Human thyroid anchoring protein 31
    • Human thyroid-anchoring protein 31
    • LBC
    • LBC oncogene
    • Lymphoid blast crisis oncogene
    • Non oncogenic Rho GTPase specific GTP exchange factor
    • Non-oncogenic Rho GTPase-specific GTP exchange factor
    • p47
    • Protein kinase A anchoring protein 13
    • Protein kinase A-anchoring protein 13
    • PROTO LB
    • PROTO LBC
    see all
  • Function

    Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.
  • Tissue specificity

    Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver.
  • Sequence similarities

    Contains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
  • Domain

    Both the DH and PH domains are required for transforming activity.
  • Cellular localization

    Cytoplasm; Cytoplasm. Nucleus and Membrane.
  • Target information above from: UniProt accession Q12802 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (0)

Publishing research using ab127097? Please let us know so that we can cite the reference in this datasheet.

ab127097 has not yet been referenced specifically in any publications.

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