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    products/proteins-peptides/recombinant-human-bax-protein-ab173026.pdf

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Cell Biology Apoptosis Intracellular Associated Proteins
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Recombinant Human Bax protein (ab173026)

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SDS-PAGE - Recombinant Human Bax protein (ab173026)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Tags: His tag C-Terminus, His tag N-Terminus
    • Suitable for: HPLC, SDS-PAGE

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    Description

    • Product name

      Recombinant Human Bax protein
      See all Bax proteins and peptides
    • Purity

      > 95 % SDS-PAGE.
      Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      Escherichia coli
    • Accession

      Q07812
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MGSSHHHHHHSSGLVPRGSHMDGSGEQPRGGGPTSSEQIMKTGALLLQGF IQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMI AAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVP ELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQLEHHHHHH
      • Predicted molecular weight

        22 kDa including tags
      • Amino acids

        1 to 171
      • Tags

        His tag C-Terminus , His tag N-Terminus

    Associated products

    • Related Products

      • 2-Methoxyantimycin A3, Bcl-xL and Bcl-2 inhibitor (ab141523)
      • Anti-6X His tag® antibody [HIS.H8] (ab18184)
      • Anti-6X His tag® antibody [4D11] (ab5000)
      • Anti-6X His tag® antibody (ab9108)

    Specifications

    Our Abpromise guarantee covers the use of ab173026 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      HPLC

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituents: 64% Sodium chloride, 3% Sodium phosphate monobasic, monohydrate, 28% disodium;hydrogen phosphate;dodecahydrate

      Lyophilized from a 0.2 µm filtered solution

    General Info

    • Alternative names

      • Apoptosis regulator BAX
      • BAX
      • Bax-protein
      • BAX_HUMAN
      • BAXA
      • Baxdelta2G9
      • Baxdelta2G9omega
      • Baxdelta2omega
      • Bcl-2-like protein 4
      • BCL2 associated X protein
      • BCL2 associated X protein omega
      • BCL2 associated X protein transcript variant delta2
      • Bcl2-L-4
      • BCL2L4
      • membrane isoform alpha
      see all
    • Function

      Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
    • Tissue specificity

      Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
    • Sequence similarities

      Belongs to the Bcl-2 family.
    • Domain

      Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
    • Cellular localization

      Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
    • Target information above from: UniProt accession Q07812 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Bax protein (ab173026)
      SDS-PAGE - Recombinant Human Bax protein (ab173026)

      SDS-PAGE analysis of ab173026.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab173026? Please let us know so that we can cite the reference in this datasheet.

    ab173026 has not yet been referenced specifically in any publications.

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