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    products/proteins-peptides/recombinant-human-gdf-5-protein-ab52315.pdf

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Cardiovascular Angiogenesis Growth Factors TGF
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Recombinant Human GDF 5 protein (ab52315)

  • Datasheet
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Key features and details

  • Expression system: Escherichia coli
  • Purity: >= 98% SDS-PAGE
  • Active: Yes
  • Suitable for: Phosphatase Activity, SDS-PAGE

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Description

  • Product name

    Recombinant Human GDF 5 protein
    See all GDF 5 proteins and peptides
  • Biological activity

    The EC50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1-10 µg/ml.

  • Purity

    >= 98 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

    P43026
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      APLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEG LCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDS ANNVVYKQYEDMVVESCGCR

Specifications

Our Abpromise guarantee covers the use of ab52315 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Phosphatase Activity

    SDS-PAGE

  • Form

    Lyophilized
  • Additional notes

    This product is manufactured by BioVision, an Abcam company and was previously called 4580 BMP-14 (GDF-5/CDMP-1), human recombinant. 4580-50 is the same size as the 50 µg size of ab52315.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: 0.294% Sodium citrate

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute to a concentration of 0.1-1.0 mg/ml in water containing BSA (50 µg BSA per 1 µg of protein). This solution can then be diluted into other aqueous buffers.

General Info

  • Alternative names

    • BMP14
    • Cartilage derived morphogenetic protein 1
    • Cartilage-derived morphogenetic protein 1
    • CDMP-1
    • CDMP1
    • GDF-5
    • Gdf5
    • GDF5_HUMAN
    • Growth differentiation factor 5
    • Growth/differentiation factor 5
    • LAP4
    • OS5
    • Radotermin
    • SYNS2
    see all
  • Function

    Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B.
  • Tissue specificity

    Predominantly expressed in long bones during embryonic development.
  • Involvement in disease

    Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG) [MIM:200700]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDG is an autosomal recessive form characterized by normal axial skeletons and missing or fused skeletal elements within the hands and feet.
    Defects in GDF5 are the cause of acromesomelic chondrodysplasia Hunter-Thompson type (AMDH) [MIM:201250]. AMDH is an autosomal recessive form of dwarfism. Patients have limb abnormalities, with the middle and distal segments being most affected and the lower limbs more affected than the upper. AMDH is characterized by normal axial skeletons and missing or fused skeletal elements within the hands and feet.
    Defects in GDF5 are the cause of brachydactyly type C (BDC) [MIM:113100]. BDC is an autosomal dominant disorder characterized by an abnormal shortness of the fingers and toes.
    Defects in GDF5 are the cause of Du Pan syndrome (DPS) [MIM:228900]; also known as fibular hypoplasia and complex brachydactyly. Du Pan syndrome is a rare autosomal recessive condition characterized by absence of the fibulae and severe acromesomelic limb shortening with small, non-functional toes. Although milder, the phenotype resembles the autosomal recessive Hunter-Thompson [MIM:201250] and Grebe types [MIM:200700] of acromesomelic chondrodysplasia.
    Defects in GDF5 are a cause of symphalangism proximal syndrome (SYM1) [MIM:185800]. SYM1 is characterized by the hereditary absence of the proximal interphalangeal (PIP) joints (Cushing symphalangism). Severity of PIP joint involvement diminishes towards the radial side. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conducive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.
    Defects in GDF5 are the cause of multiple synostoses syndrome type 2 (SYNS2) [MIM:610017]. Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness.
    Defects in GDF5 are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits.
    Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5) [MIM:612400]. Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement.
    Defects in GDF5 may be a cause of brachydactyly type A1 (BDA1) [MIM:112500]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits.
  • Sequence similarities

    Belongs to the TGF-beta family.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession P43026 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (0)

Publishing research using ab52315? Please let us know so that we can cite the reference in this datasheet.

ab52315 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Question

Can this proten be used in cell culture?

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Abcam community

Verified customer

Asked on Dec 01 2011

Answer

Thank you for contacting us. Yes, this product can be used in cell culture. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.  

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Abcam Scientific Support

Answered on Dec 01 2011

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