Recombinant Human HNF-4-alpha protein (ab132090)

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SDS-PAGE - Recombinant Human HNF-4-alpha protein (ab132090)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: WB, SDS-PAGE, ELISA

    Description

    • Product name

      Recombinant Human HNF-4-alpha protein

    • Expression system

      Wheat germ

    • Accession

      P41235

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNA PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSR QCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLP SINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVE WAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYI VPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQ MIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGT NVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGAVATIVKPL SAIPQPTITKQEVI

      • Predicted molecular weight

        78 kDa including tags

      • Amino acids

        1 to 464

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab132090 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      SDS-PAGE

      ELISA

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • FLJ39654
      • FRTS4
      • Hepatic nuclear factor 4 alpha
      • Hepatocyte nuclear factor 4
      • Hepatocyte nuclear factor 4 alpha
      • Hepatocyte nuclear factor 4-alpha
      • HNF 4
      • HNF 4 alpha
      • HNF-4-alpha
      • HNF4
      • HNF4A
      • HNF4A_HUMAN
      • HNF4a7
      • HNF4a8
      • HNF4a9
      • Hnf4alpha
      • HNF4alpha10/11/12
      • MODY
      • MODY 1
      • MODY1
      • NR2A1
      • NR2A21
      • Nuclear receptor subfamily 2 group A member 1
      • OTTHUMP00000031060
      • OTTHUMP00000031062
      • TCF
      • TCF 14
      • TCF-14
      • TCF14
      • Tcf4
      • Transcription factor 14, hepatic nuclear factor
      • Transcription factor 14
      • Transcription factor HNF 4
      • Transcription factor HNF-4
      • Transcription factor HNF4
      see all

    • Function

      Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

    • Involvement in disease

      Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:125850]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

    • Sequence similarities

      Belongs to the nuclear hormone receptor family. NR2 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.

    • Post-translational
      modifications

      Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.

    • Cellular localization

      Nucleus.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human HNF-4-alpha protein (ab132090)
      SDS-PAGE - Recombinant Human HNF-4-alpha protein (ab132090)
      12.5% SDS-PAGE stained with Coomassie Blue showing ab132090 at approximately 78 kDa.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab132090? Please let us know so that we can cite the reference in this datasheet.

    ab132090 has not yet been referenced specifically in any publications.

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