Recombinant human MERTK protein (ab72490)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 90% Densitometry
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Description
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Product name
Recombinant human MERTK protein
See all MERTK proteins and peptides -
Biological activity
The Specific activity of ab72490 was determined to be 1231 nmol/min/mg.
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Purity
> 90 % Densitometry.
Affinity purified. -
Expression system
Baculovirus infected Sf9 cells -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Amino acids
578 to 872
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Associated products
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Substrate reagent
Specifications
Our Abpromise guarantee covers the use of ab72490 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Functional Studies
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Form
Liquid -
Additional notes
ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.00174% PMSF, 0.0038% EGTAThis product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
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Alternative names
- c MER
- c mer proto oncogene tyrosine kinase
- c-mer
see all -
Function
In case of filovirus infection, seems to function as a cell entry factor. -
Tissue specificity
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. -
Involvement in disease
Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
Images
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Functional Studies - Recombinant human MERTK protein (ab72490)The specific activity of MERTK (ab72490) was determined to be 1046 nmol/min/mg as per activity assay protocol
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SDS-PAGE - Recombinant human MERTK protein (ab72490)SDS PAGE analysis of ab72490 -
SDS-PAGE - Recombinant human MERTK protein (ab72490)SDS PAGE analysis of ab72490 -
Functional Studies - Recombinant human MERTK protein (ab72490)Kinase Assay demonstrating specific activity of ab72490. -
SDS-PAGE - Recombinant human MERTK protein (ab72490)SDS-PAGE showing ab72490 at approximately 58kDa.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab72490 has not yet been referenced specifically in any publications.