Recombinant Human PRKAR1A protein (ab125532)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 85% Densitometry
- Suitable for: WB, SDS-PAGE
Description
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Product name
Recombinant Human PRKAR1A protein -
Purity
> 85 % Densitometry.
Purity determined to be >85% by densitometry. Affinity purified. -
Expression system
Baculovirus infected Sf9 cells -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Predicted molecular weight
51 kDa including tags -
Amino acids
1 to 381
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab125532 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
SDS-PAGE
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Form
Liquid -
Additional notes
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
This product was previously labelled as Protein Kinase A regulatory subunit I alpha
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.00
Preservative: 1.02% Imidazole
Constituents: 0.002% PMSF, 0.82% Sodium phosphate, 0.0038% DTT, 25% Glycerol (glycerin, glycerine), 1.75% Sodium chloride
General Info
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Alternative names
- ACRDYS1
- ADOHR
- cAMP dependent protein kinase regulatory subunit alpha 1
see all -
Tissue specificity
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. -
Involvement in disease
Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
Defects in PRKAR1A are the cause of intracardiac myxoma (INTMYX) [MIM:255960]. Inheritance is autosomal recessive.
Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history. -
Sequence similarities
Belongs to the cAMP-dependent kinase regulatory chain family.
Contains 2 cyclic nucleotide-binding domains. -
Post-translational
modificationsThe pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human PRKAR1A protein (ab125532)SDS-PAGE analysis of ab125532.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab125532 has not yet been referenced specifically in any publications.