Recombinant Human SOS1 protein (His tag) (ab233594)
Key features and details
- Expression system: Baculovirus infected insect cells
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 1.000 Eu/µg
- Tags: His tag C-Terminus
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Human SOS1 protein (His tag) -
Purity
> 95 % SDS-PAGE.
Affinity purified -
Endotoxin level
< 1.000 Eu/µg -
Expression system
Baculovirus infected insect cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
ADPEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLI ERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL LQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPT VEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWT KEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQ VFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSED HYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLF NKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTHHHHHH -
Predicted molecular weight
58 kDa including tags -
Amino acids
562 to 1052 -
Tags
His tag C-Terminus -
Additional sequence information
NP_005624
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab233594 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.50
Constituents: 0.32% Tris HCl, 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.02% DTT, 0.02% Magnesium chloride
General Info
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Alternative names
- alternate SOS1
- GF1
- GGF1
see all -
Function
Promotes the exchange of Ras-bound GDP by GTP. -
Tissue specificity
Expressed in gingival tissues. -
Involvement in disease
Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common.
Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common. -
Sequence similarities
Contains 1 DH (DBL-homology) domain.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 PH domain.
Contains 1 Ras-GEF domain. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human SOS1 protein (His tag) (ab233594)
15% SDS-PAGE analysis of 3 µg ab233594.
MW: 50-70 kDa (SDS-PAGE under reducing conditions).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab233594 has not yet been referenced specifically in any publications.