Recombinant Mouse ACE2 protein (Fc Chimera His Tag) (ab276801)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level: < 1.000 Eu/µg
- Tags: His tag C-Terminus, Fc tag C-Terminus
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Mouse ACE2 protein (Fc Chimera His Tag)
See all ACE2 proteins and peptides -
Purity
> 95 % SDS-PAGE. -
Endotoxin level
< 1.000 Eu/µg -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Sequence
MSSSSWLLLS LVAVTTAQSL TEENAKTFLN NFNQEAEDLS YQSSLASWNY NTNITEENAQ KMSEAAAKWS AFYEEQSKTA QSFSLQEIQT PIIKRQLQAL QQSGSSALSA DKNKQLNTIL NTMSTIYSTG KVCNPKNPQE CLLLEPGLDE IMATSTDYNS RLWAWEGWRA EVGKQLRPLY EEYVVLKNEM ARANNYNDYG DYWRGDYEAE GADGYNYNRN QLIEDVERTF AEIKPLYEHL HAYVRRKLMD TYPSYISPTG CLPAHLLGDM WGRFWTNLYP LTVPFAQKPN IDVTDAMMNQ GWDAERIFQE AEKFFVSVGL PHMTQGFWAN SMLTEPADGR KVVCHPTAWD LGHGDFRIKM CTKVTMDNFL TAHHEMGHIQ YDMAYARQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS IGLLPSDFQE DSETEINFLL KQALTIVGTL PFTYMLEKWR WMVFRGEIPK EQWMKKWWEM KREIVGVVEP LPHDETYCDP ASLFHVSNDY SFIRYYTRTI YQFQFQEALC QAAKYNGSLH KCDISNSTEA GQKLLKMLSL GNSEPWTKAL ENVVGARNMD VKPLLNYFQP LFDWLKEQNR NSFVGWNTEW SPYADQSIKV RISLKSALGA NAYEWTNNEM FLFRSSVAYA MRKYFSIIKN QTVPFLEEDV RVSDLKPRVS FYFFVTSPQN VSDVIPRSEV EDAIRMSRGR INDVFGLNDN SLEFLGIHPT LEPPYQPPVT -
Predicted molecular weight
112 kDa including tags -
Molecular weight information
The secreted recombinant mouse ACE2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 971 amino acids and has a predicted molecular mass of 112 kDa. As a result of glycosylation, it migrates as an approximately 130 kDa band in SDS-PAGE under reducing conditions. -
Amino acids
1 to 740 -
Tags
His tag C-Terminus , Fc tag C-Terminus -
Additional sequence information
Fc region of human IgG1.Predicted N-terminus: Gln 18.
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Specifications
Our Abpromise guarantee covers the use of ab276801 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at Room Temperature. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.5
Constituents: 0.24% Tris, 0.87% Sodium chloride, 0.01% Zinc chloride -
ReconstitutionThis information is lot specific. Please contact our technical Support team for details.
General Info
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Alternative names
- ACE 2
- ACE related carboxypeptidase
- ACE-related carboxypeptidase
see all -
Function
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. -
Tissue specificity
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. -
Sequence similarities
Belongs to the peptidase M2 family. -
Post-translational
modificationsN-glycosylation on Asn-90 may limit SARS infectivity. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Mouse ACE2 protein (ab276801)SDS-PAGE analysis of ab276801
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab276801 has not yet been referenced specifically in any publications.
