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  1. Link

    products/proteins-peptides/recombinant-mouse-ace2-protein-fc-chimera-his-tag-ab276801.pdf

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Microbiology Organism Virus RNA Virus ssRNA positive strand virus SARS Coronavirus
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Recombinant Mouse ACE2 protein (Fc Chimera His Tag) (ab276801)

  • Datasheet
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SDS-PAGE - Recombinant Mouse ACE2 protein (ab276801)

    Key features and details

    • Expression system: HEK 293 cells
    • Purity: > 95% SDS-PAGE
    • Endotoxin level: < 1.000 Eu/µg
    • Tags: His tag C-Terminus, Fc tag C-Terminus
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Mouse ACE2 protein (Fc Chimera His Tag)
      See all ACE2 proteins and peptides
    • Purity

      > 95 % SDS-PAGE.

    • Endotoxin level

      < 1.000 Eu/µg
    • Expression system

      HEK 293 cells
    • Accession

      Q8R0I0-1
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Mouse
      • Sequence

        MSSSSWLLLS LVAVTTAQSL TEENAKTFLN NFNQEAEDLS YQSSLASWNY NTNITEENAQ KMSEAAAKWS AFYEEQSKTA QSFSLQEIQT PIIKRQLQAL QQSGSSALSA DKNKQLNTIL NTMSTIYSTG KVCNPKNPQE CLLLEPGLDE IMATSTDYNS RLWAWEGWRA EVGKQLRPLY EEYVVLKNEM ARANNYNDYG DYWRGDYEAE GADGYNYNRN QLIEDVERTF AEIKPLYEHL HAYVRRKLMD TYPSYISPTG CLPAHLLGDM WGRFWTNLYP LTVPFAQKPN IDVTDAMMNQ GWDAERIFQE AEKFFVSVGL PHMTQGFWAN SMLTEPADGR KVVCHPTAWD LGHGDFRIKM CTKVTMDNFL TAHHEMGHIQ YDMAYARQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS IGLLPSDFQE DSETEINFLL KQALTIVGTL PFTYMLEKWR WMVFRGEIPK EQWMKKWWEM KREIVGVVEP LPHDETYCDP ASLFHVSNDY SFIRYYTRTI YQFQFQEALC QAAKYNGSLH KCDISNSTEA GQKLLKMLSL GNSEPWTKAL ENVVGARNMD VKPLLNYFQP LFDWLKEQNR NSFVGWNTEW SPYADQSIKV RISLKSALGA NAYEWTNNEM FLFRSSVAYA MRKYFSIIKN QTVPFLEEDV RVSDLKPRVS FYFFVTSPQN VSDVIPRSEV EDAIRMSRGR INDVFGLNDN SLEFLGIHPT LEPPYQPPVT
      • Predicted molecular weight

        112 kDa including tags
      • Molecular weight information

        The secreted recombinant mouse ACE2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 971 amino acids and has a predicted molecular mass of 112 kDa. As a result of glycosylation, it migrates as an approximately 130 kDa band in SDS-PAGE under reducing conditions.
      • Amino acids

        1 to 740
      • Tags

        His tag C-Terminus , Fc tag C-Terminus
      • Additional sequence information

        Fc region of human IgG1.Predicted N-terminus: Gln 18.

    Specifications

    Our Abpromise guarantee covers the use of ab276801 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at Room Temperature. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.5
      Constituents: 0.24% Tris, 0.87% Sodium chloride, 0.01% Zinc chloride

    • Reconstitution
      This information is lot specific. Please contact our technical Support team for details.

    General Info

    • Alternative names

      • ACE 2
      • ACE related carboxypeptidase
      • ACE-related carboxypeptidase
      • ACE2
      • ACE2_HUMAN
      • ACEH
      • Angiotensin converting enzyme 2
      • Angiotensin converting enzyme homolog
      • Angiotensin converting enzyme like protein
      • Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2
      • Angiotensin I converting enzyme 2
      • Angiotensin-converting enzyme homolog
      • DKFZP434A014
      • EC 3.4.17
      • metalloprotease MPROT 15
      • Metalloprotease MPROT15
      • OTTHUMP00000022963
      • Processed angiotensin-converting enzyme 2
      see all
    • Function

      Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
    • Tissue specificity

      Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
    • Sequence similarities

      Belongs to the peptidase M2 family.
    • Post-translational
      modifications

      N-glycosylation on Asn-90 may limit SARS infectivity.
    • Cellular localization

      Secreted and Cell membrane.
    • Target information above from: UniProt accession Q9BYF1 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Mouse ACE2 protein (ab276801)
      SDS-PAGE - Recombinant Mouse ACE2 protein (ab276801)
      SDS-PAGE analysis of ab276801

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download

    References (0)

    Publishing research using ab276801? Please let us know so that we can cite the reference in this datasheet.

    ab276801 has not yet been referenced specifically in any publications.

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