Recombinant Rabbit IL-6 protein (ab289783)
Key features and details
- Expression system: Yeast
- Purity: >= 90% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE
Description
-
Product name
Recombinant Rabbit IL-6 protein
See all IL-6 proteins and peptides -
Purity
>= 90 % SDS-PAGE. -
Expression system
Yeast -
Accession
-
Protein length
Full length protein -
Animal free
Yes -
Nature
Recombinant -
-
Species
Rabbit -
Sequence
FPTSAPVRED SNTKASPDKT LTPPGRTIES IRSILETIKE LRKEMCDHDV NCMNRKEALA EVNLHLPRLI EEDGCFPPAV NNETCLLRIT SGLMEFRMYL EHLQAKFRSD EENTRVSMVL KNIQHLIKTL RPKVKNLNEE ATLKPAVAVS LMENLQQKNQ WLKTTTIHFI LRGLTNFLEF TLRAVDLMEC GCPCLRNFMG SASHGQNTPS CPLDT -
Predicted molecular weight
26 kDa including tags -
Amino acids
27 to 241 -
Tags
His tag N-Terminus -
Additional sequence information
6xHis Full-length mature chain
-
Specifications
Our Abpromise guarantee covers the use of ab289783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
Applications
SDS-PAGE
-
Form
Lyophilized -
Concentration information loading...
Preparation and Storage
-
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40
Constituents: 0.24% Tris, 2.9% Sodium chloride, 6% Trehalose, 0.075% Hydrochloric acid
General Info
-
Alternative names
- Interleukin BSF 2
- B cell differentiation factor
- B cell stimulatory factor 2
see all -
Function
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. -
Involvement in disease
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. -
Sequence similarities
Belongs to the IL-6 superfamily. -
Post-translational
modificationsN- and O-glycosylated. -
Cellular localization
Secreted. - Information by UniProt
Images
-
SDS-PAGE - Recombinant Rabbit IL-6 protein (ab289783)SDS-PAGE analysis of ab289783
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
Datasheet download
References (0)
ab289783 has not yet been referenced specifically in any publications.
