Key features and details
- Guinea pig polyclonal to ProDynorphin
- Suitable for: IHC-Fr
- Reacts with: Mouse, Rat
- Isotype: IgG
Product nameAnti-ProDynorphin antibody
See all ProDynorphin primary antibodies
DescriptionGuinea pig polyclonal to ProDynorphin
Host speciesGuinea pig
Tested applicationsSuitable for: IHC-Frmore details
Species reactivityReacts with: Mouse, Rat
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.05% Sodium azide
Concentration information loading...
PurityProtein A purified
Primary antibody notesThe protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine.
Our Abpromise guarantee covers the use of ab10280 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionLeu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
Involvement in diseaseDefects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
Sequence similaritiesBelongs to the opioid neuropeptide precursor family.
modificationsThe N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
- Information by UniProt
- ADCA antibody
- Alpha neoendorphin antibody
- Beta neoendorphin antibody
ab10280 has been referenced in 1 publication.
- Bröhl D et al. A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord. Dev Biol 322:381-93 (2008). IHC-Fr ; Mouse . PubMed: 18721803