Overview

  • Product name

    Anti-Prolactin Receptor/PRL-R antibody [SPM213] - BSA and Azide free
    See all Prolactin Receptor/PRL-R primary antibodies
  • Description

    Mouse monoclonal [SPM213] to Prolactin Receptor/PRL-R - BSA and Azide free
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human Prolactin Receptor/PRL-R. (Semi-purified).
    Database link: P16471

  • Positive control

    • IHC-P: Human testicular carcinoma tissue.
  • General notes

    Previously labelled as Prolactin Receptor. 

Properties

Applications

Our Abpromise guarantee covers the use of ab212747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml.

Staining of formalin/paraffin tissues requires digestion of tissue sections with pepsin at 1mg/ml Tris-HCl, pH 2.0 for 15 min at RT or 10 min at 37C.

(Primary incubation for 30 minutes at RT).

Target

  • Function

    This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
  • Tissue specificity

    Expressed in breast, placenta, kidney, liver and pancreas.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 1 subfamily.
    Contains 2 fibronectin type-III domains.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization

    Secreted and Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AI987712 antibody
    • CLONE SPM213 antibody
    • CPRLP antibody
    • Delta 4-delta 7/11 truncated prolactin receptor antibody
    • Delta 4-SF1b truncated prolactin receptor antibody
    • HPRL antibody
    • hPRL receptor antibody
    • hPRLrI antibody
    • Lactogen receptor antibody
    • MFAB antibody
    • MGC105486 antibody
    • OPR antibody
    • OTTHUMP00000115998 antibody
    • Pr-1 antibody
    • Pr-3 antibody
    • PRL R antibody
    • PRL-R antibody
    • PRLR antibody
    • Prlr-rs1 antibody
    • PRLR_HUMAN antibody
    • Prolactin receptor a antibody
    • Prolactin receptor antibody
    • Prolactin receptor delta 7/11 antibody
    • RATPRLR antibody
    • Secreted prolactin binding protein antibody
    • Truncated testis-specific box 1-C prolactin receptor antibody
    • wu:fj65c07 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human testicular carcinoma tissue stained for Prolactin Receptor/PRL-R using ab212747 at 1 µg/ml in immunohistochemical analysis.

    This IHC-P data was generated using the same anti-Prolactin Receptor/PRL-R antibody clone, SPM213, in a different buffer formulation.

References

ab212747 has not yet been referenced specifically in any publications.

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