Propafenone hydrochloride, Na+, Ca2+ and K+ channel blocker (ab142357)

Overview

  • Product name

    Propafenone hydrochloride, Na+, Ca2+ and K+ channel blocker
  • Description

    Na+, Ca2+ and K+ channel blocker
  • Biological description

    Na+, Ca2+ and K+ channel blocker. Suppresses atrial fibrillation in vivo. Blocks ATP-sensitive K+ channels reversibly and voltage-independently (EC50 values are 1 and 5 μM for atrial and ventricular myocytes, respectively). Orally active.
  • Purity

    > 98%
  • CAS Number

    34183-22-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Burashnikov A  et al. Atrial-selective sodium channel block strategy to suppress atrial fibrillation: ranolazine versus propafenone. J Pharmacol Exp Ther 340:161-8 (2012). Read more (PubMed: 22005044) »
  • Burashnikov A & Antzelevitch C New pharmacological strategies for the treatment of atrial fibrillation. Ann Noninvasive Electrocardiol 14:290-300 (2009). Read more (PubMed: 19614642) »
  • Christé G  et al. Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. Eur J Pharmacol 373:223-32 (1999). Read more (PubMed: 10414443) »

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