Overview

  • Product name

    Anti-Properdin/PFC antibody [10-18]
    See all Properdin/PFC primary antibodies
  • Description

    Mouse monoclonal [10-18] to Properdin/PFC
  • Host species

    Mouse
  • Tested applications

    Suitable for: ELISA, IHC-Fr, Functional Studiesmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Human Properdin/PFC.

  • Positive control

    • Histology positive control tissue: Kidney from post streptococcal glomerulonephritis patients.
  • General notes

     This product was previously labelled as Properdin

     

Properties

Applications

Our Abpromise guarantee covers the use of ab58984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IHC-Fr
Functional Studies
  • Application notes
    ELISA: Use at an assay dependent dilution.
    FuncS: Use at an assay dependent dilution.
    Note: This antibody inhibits the function of Properdin. Removal of sodium azide is recommended prior to use in functional assays
    IHC-Fr: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
    • Involvement in disease

      Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
    • Sequence similarities

      Contains 6 TSP type-1 domains.
    • Cellular localization

      Secreted.
    • Information by UniProt
    • Database links

    • Alternative names

      • BFD antibody
      • CFP antibody
      • Complement factor P antibody
      • Complement factor properdin antibody
      • Factor P antibody
      • PFC antibody
      • PFD antibody
      • PROP_HUMAN antibody
      • Properdin antibody
      • Properdin P factor complement antibody
      see all

    References

    ab58984 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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