Anti-Properdin/PFC antibody [10C5] (ab17780)
- Datasheet
- References
- Protocols
Overview
-
Product nameAnti-Properdin/PFC antibody [10C5]
See all Properdin/PFC primary antibodies -
DescriptionMouse monoclonal [10C5] to Properdin/PFC
-
Host speciesMouse
-
Tested applicationsSuitable for: ELISA, WBmore details
-
Species reactivityReacts with: Human
-
Immunogen
Full length native protein (purified) corresponding to Human Properdin/PFC.
-
General notes
This product was previously labelled as Properdin
Properties
-
FormLiquid
-
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
-
Storage bufferpH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading... -
PurityProtein G purified
-
ClonalityMonoclonal
-
Clone number10C5
-
Myelomax63-Ag8.653
-
IsotypeIgG1
-
Light chain typekappa
-
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
Our Abpromise guarantee covers the use of ab17780 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | ||
| WB |
Application notes
ELISA: 1/10000.
WB: Use at an assay dependent dilution. Predicted molecular weights: 25, 56 (reduced) and 220 kDa (unreduced).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weights: 25, 56 (reduced) and 220 kDa (unreduced).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
-
FunctionA positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
-
Involvement in diseaseDefects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
-
Sequence similaritiesContains 6 TSP type-1 domains.
-
Cellular localizationSecreted.
- Information by UniProt
-
Database links
- Entrez Gene: 5199 Human
- Omim: 300383 Human
- SwissProt: P27918 Human
- Unigene: 53155 Human
-
Alternative names
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
Protocols
References
ab17780 has not yet been referenced specifically in any publications.
