Anti-Properdin/PFC antibody [10C5] (ab17780)
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- References
- Protocols
Overview
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Product name
Anti-Properdin/PFC antibody [10C5]
See all Properdin/PFC primary antibodies -
Description
Mouse monoclonal [10C5] to Properdin/PFC -
Host species
Mouse -
Tested applications
Suitable for: ELISA, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Full length native protein (purified) corresponding to Human Properdin/PFC.
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General notes
This product was previously labelled as Properdin
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
10C5 -
Myeloma
x63-Ag8.653 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab17780 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | 1/10000. | |
| WB | Use at an assay dependent dilution. Predicted molecular weight: 25, 56 , 220 kDa. |
Target
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Function
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. -
Involvement in disease
Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III). -
Sequence similarities
Contains 6 TSP type-1 domains. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 5199 Human
- Omim: 300383 Human
- SwissProt: P27918 Human
- Unigene: 53155 Human
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Alternative names
- BFD antibody
- CFP antibody
- Complement factor P antibody
see all
Protocols
References
ab17780 has not yet been referenced specifically in any publications.
