Key features and details
- Rabbit polyclonal to Properdin/PFC
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Properdin/PFC antibody
See all Properdin/PFC primary antibodies
DescriptionRabbit polyclonal to Properdin/PFC
Tested applicationsSuitable for: ICC/IF, WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Recombinant full length protein corresponding to Human Properdin/PFC aa 1-469.
Database link: P27918
This product was previously labelled as Properdin
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab186834 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use at an assay dependent concentration.|
|WB||1/500 - 1/2000. Predicted molecular weight: 51 kDa.|
FunctionA positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
Involvement in diseaseDefects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
Sequence similaritiesContains 6 TSP type-1 domains.
- Information by UniProt
- BFD antibody
- CFP antibody
- Complement factor P antibody
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186834. Blue DAPI for nuclear staining.
All lanes : Anti-Properdin/PFC antibody (ab186834) at 1/500 dilution
Lane 1 : Extracts from 293T cell line
Lane 2 : Extracts from 3T3L1 cell line
Lane 3 : Extracts from mouse liver
Lane 4 : Extracts from mouse brain
Lane 5 : Extracts from mouse kidney
Predicted band size: 51 kDa
ab186834 has not yet been referenced specifically in any publications.