Overview

  • Product name

    Anti-Prorenin antibody [6E2-B7]
    See all Prorenin primary antibodies
  • Description

    Mouse monoclonal [6E2-B7] to Prorenin
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Sheep, Dog, Chimpanzee, Cynomolgus monkey, Rhesus monkey
  • Immunogen

    Recombinant full length protein corresponding to Human Prorenin. (Glycosylated).
    Database link: P00797

  • Epitope

    Recognises amino acid residues 16-29 (MPSIRESLKERGVD) of the prosegment of Prorenin.
  • Positive control

    • Human kidney tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 6.60
    Constituents: 0.58% Sodium chloride, 0.03% EDTA, 0.82% Sodium phosphate
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    6E2-B7
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab219071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • Involvement in disease

    Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
  • Sequence similarities

    Belongs to the peptidase A1 family.
  • Cellular localization

    Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
  • Information by UniProt
  • Database links

  • Alternative names

    • Angiotensin forming enzyme antibody
    • Angiotensinogenase antibody
    • FLJ10761 antibody
    • HNFJ2 antibody
    • REN antibody
    • Ren1 antibody
    • RENAA antibody
    • RENI_HUMAN antibody
    • Renin antibody
    • Renin precursor renal antibody
    • Renin-1 antibody
    • Renin-2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue labeling Prorenin with ab219071 at 20 μg/ml.

References

ab219071 has not yet been referenced specifically in any publications.

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