Anti-ProSAAS antibody (ab191283)
Key features and details
- Goat polyclonal to ProSAAS
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ProSAAS antibody -
Description
Goat polyclonal to ProSAAS -
Host species
Goat -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rabbit, Guinea pig, Chimpanzee, Monkey, Gorilla -
Immunogen
Synthetic peptide corresponding to Human ProSAAS aa 150-250 (internal sequence) (Cysteine residue).
Database link: Q9UHG2 -
Positive control
- Human pancreas tissue.
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General notes
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab191283 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known. -
Tissue specificity
Expressed in brain and pancreas. -
Domain
ProSAAS(1-180) increases secretion of enzymatically inactive PCSK1.
The C-terminal inhibitory domain is involved in inhibtion of PCSK1. It corresponds to the probable processing intermediate Big PEN-LEN, binds to PCSK1 in vitro and contains the hexapeptide L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for PCSK1 inhibition. -
Post-translational
modificationsProteolytically cleaved in the Golgi.
O-glycosylated with a core 1 or possibly core 8 glycan. -
Cellular localization
Secreted. Golgi apparatus > trans-Golgi network. A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. - Information by UniProt
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Database links
- Entrez Gene: 101149766 Gorilla
- Entrez Gene: 100731521 Guinea pig
- Entrez Gene: 27344 Human
- Entrez Gene: 30052 Mouse
- Omim: 300399 Human
- SwissProt: Q9UHG2 Human
- SwissProt: Q9QXV0 Mouse
- Unigene: 522640 Human
see all -
Alternative names
- b-LEN antibody
- b-PEN-LEN antibody
- b-SAAS antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab191283 has not yet been referenced specifically in any publications.