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Immunology Innate Immunity Macrophage / Inflamm.
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Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab62050)

  • Datasheet
  • SDS
Reviews (3) Submit a question References (7)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab62050)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab62050)

Key features and details

  • Rabbit polyclonal to Prostaglandin E Synthase/MPGES-1
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Protein
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Recombinant Human Prostaglandin E Synthase/MPGES-1 protein (ab160537)
Primary
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Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody [EP12357] (ab182141)
Secondary
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Prostaglandin E Synthase/MPGES-1 antibody
    See all Prostaglandin E Synthase/MPGES-1 primary antibodies
  • Description

    Rabbit polyclonal to Prostaglandin E Synthase/MPGES-1
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to Human Prostaglandin E Synthase/MPGES-1 (N terminal) conjugated to keyhole limpet haemocyanin.

  • General notes

    Previously labelled as Prostaglandin E Synthase

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Macrophage / Inflamm.
    • Signal Transduction
    • Signaling Pathway
    • Lipid Signaling
    • Prostaglandins
    • Immunology
    • Immune System Diseases
    • Autoimmune

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Prostaglandin E Synthase/MPGES-1 protein (ab160537)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab62050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Human
All applications
Rat
Rabbit
Chicken
Cow
Dog
Pig
Xenopus laevis
Monkey
Zebrafish
Application Abreviews Notes
IHC-P (1)
Use a concentration of 10 µg/ml.
Notes
IHC-P
Use a concentration of 10 µg/ml.

Target

  • Function

    Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
  • Sequence similarities

    Belongs to the MAPEG family.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession O14684 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 417193 Chicken
    • Entrez Gene: 282019 Cow
    • Entrez Gene: 9536 Human
    • Entrez Gene: 59103 Rat
    • Entrez Gene: 544666 Zebrafish
    • Omim: 605172 Human
    • SwissProt: O14684 Human
    • Unigene: 146688 Human
    • Alternative names

      • Glutathione S transferase 1 like 1 antibody
      • MGC10317 antibody
      • MGST IV antibody
      • MGST1 L1 antibody
      • MGST1 like 1 antibody
      • MGST1-L1 antibody
      • MGST1L1 antibody
      • MGSTIV antibody
      • Microsomal glutathione S transferase 1 like 1 antibody
      • Microsomal glutathione S-transferase 1-like 1 antibody
      • Microsomal prostaglandin E synthase 1 antibody
      • Microsomal prostaglandin E synthase 1 antibody
      • mPGES 1 antibody
      • MPGES antibody
      • mPGES-1 antibody
      • p53 induced apoptosis protein 12 antibody
      • p53 induced gene 12 antibody
      • p53 induced gene 12 protein antibody
      • p53-induced gene 12 protein antibody
      • PGES antibody
      • PIG 12 antibody
      • PIG12 antibody
      • PP 102 antibody
      • PP 1294 antibody
      • PP102 antibody
      • PP1294 antibody
      • Prostaglandin E synthase antibody
      • PTGES antibody
      • PTGES_HUMAN antibody
      • TP53I12 antibody
      • Tumor protein p53 inducible protein 12 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab62050)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab62050)This image is courtesy of an anonymous Abreview

      ab62050 staining Prostaglandin E Synthase/MPGES-1 in Mouse testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde, permeabilized with Triton-X and blocked with 10% serum for 30 minutes at 24°C; antigen retrieval was by heat mediation in a citrate buffer. Samples were incubated with primary antibody (1/50) for 20 hours at 4°C. ab150075, a donkey anti-rabbit Alexa Fluor® 647- (1/200) was used as the secondary antibody.

      See Abreview

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab62050)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Synthase/MPGES-1 antibody (ab62050)

      Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue, staining Prostaglandin E Synthase/MPGES-1 with ab62050 at 10 µg/ml.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (7)

    Publishing research using ab62050? Please let us know so that we can cite the reference in this datasheet.

    ab62050 has been referenced in 7 publications.

    • Akthar I  et al. In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb. Biochem Biophys Res Commun 527:42-48 (2020). PubMed: 32446389
    • Chen Z  et al. CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors. J Enzyme Inhib Med Chem 34:799-807 (2019). PubMed: 30879343
    • Berisha B  et al. Prostaglandins in Superovulation Induced Bovine Follicles During the Preovulatory Period and Early Corpus Luteum. Front Endocrinol (Lausanne) 10:467 (2019). PubMed: 31354631
    • Berisha B  et al. Changes in the expression of prostaglandin family members in bovine corpus luteum during the estrous cycle and pregnancy. Mol Reprod Dev 85:622-634 (2018). PubMed: 29877057
    • Maseda D  et al. mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation. Front Immunol 9:2954 (2018). PubMed: 30619314
    • Uchida K  et al. Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-a stimulation of synovial cells: an in vitro study. BMC Musculoskelet Disord 18:283 (2017). PubMed: 28668088
    • Shi X  et al. The involvement and possible mechanism of NR4A1 in chondrocyte apoptosis during osteoarthritis. Am J Transl Res 9:746-754 (2017). PubMed: 28337303

    Customer reviews and Q&As

    Show All Reviews Q&A
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    1-3 of 3 Abreviews or Q&A

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Prostaglandin E Synthase / MPGES-1 antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Mouse Tissue sections (Testis)
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: citrate buffer
    Permeabilization
    Yes - Triton-X
    Specification
    Testis
    Blocking step
    Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: 24°C
    Fixative
    Paraformaldehyde
    Read More

    Abcam user community

    Verified customer

    Submitted Dec 04 2013

    Western blot abreview for Anti-Prostaglandin E Synthase / MPGES-1 antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Mouse Cell lysate - whole cell (NIH3T3 cells)
    Gel Running Conditions
    Reduced Denaturing (8%)
    Loading amount
    20 µg
    Treatment
    24 hours IL1b stimulation (1ng/ml)
    Specification
    NIH3T3 cells
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
    Read More

    Abcam user community

    Verified customer

    Submitted Jun 10 2010

    Western blot abreview for Anti-Prostaglandin E Synthase / MPGES-1 antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Human Cell lysate - whole cell (A549 cells)
    Gel Running Conditions
    Reduced Denaturing (8%)
    Loading amount
    20 µg
    Specification
    A549 cells
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
    Read More

    Abcam user community

    Verified customer

    Submitted Jun 10 2010

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