Prostratin, PKC activator (ab120880)
Overview
-
Product name
Prostratin, PKC activator -
Description
PKC activator; reactivates HIV-1 latency -
Biological description
PKC activator; reactivates HIV-1 latency (IC50 = ~0.5 µM) by PKC dependent NF-κB activation. Downregulates expression of HIV-1 receptor CD4 and its co-receptors CXCR4 and CCR5 in vitro. Non-tumor promoting. -
Purity
> 98% -
CAS Number
60857-08-1 -
Chemical structure
Properties
-
Chemical name
12-Deoxyphorbol-13-acetate
-
Molecular weight
390.48 -
Molecular formula
C22H30O6 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in ethanol (at lot-dependent concentrations). Soluble in ethanol to 10 mg/ml.
-
Handling
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
OCC1=C[C@H]2[C@H]3[C@@](OC(=O)C)(C[C@@H](C)C2(O)C2C=C(C)C(=O)[C@@]2(O)C1)C3(C)C -
Source
Synthetic
-
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References
ab120880 has not yet been referenced specifically in any publications.
