Prostratin, PKC activator (ab120880)
- Datasheet
- References
Overview
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Product nameProstratin, PKC activator
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DescriptionPKC activator; reactivates HIV-1 latency
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Biological descriptionPKC activator; reactivates HIV-1 latency (IC50 = ~0.5 µM) by PKC dependent NF-κB activation. Downregulates expression of HIV-1 receptor CD4 and its co-receptors CXCR4 and CCR5 in vitro. Non-tumor promoting.
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Purity> 98%
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CAS Number60857-08-1
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Chemical structure
Properties
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Chemical name
12-Deoxyphorbol-13-acetate
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Molecular weight390.48
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Molecular formulaC22H30O6
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Storage instructionsStore at -20°C (desiccating conditions).
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Solubility overview
Supplied in ethanol (at lot-dependent concentrations). Soluble in ethanol to 10 mg/ml.
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Handling
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESOCC1=C[C@H]2[C@H]3[C@@](OC(=O)C)(C[C@@H](C)C2(O)C2C=C(C)C(=O)[C@@]2(O)C1)C3(C)C
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Bedoya LM et al. SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro. Biochem Pharmacol 77:965-78 (2009). Read more (PubMed: 19100719) »
- Wender PA et al. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 320:649-52 (2008). Read more (PubMed: 18451298) »
- Kulkosky J et al. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98:3006-15 (2001). Read more (PubMed: 11698284) »
