The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 21 kDa.
Use at an assay dependent concentration.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Involvement in disease
Defects in SFTPC are the cause of pulmonary surfactant metabolism dysfunction type 2 (SMDP2) [MIM:610913]; also called pulmonary alveolar proteinosis due to surfactant protein C deficiency. A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPC are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:267450]; also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
SFTPC surfactant pulmonary associated protein C antibody
SP 5 antibody
SP C antibody
Surfactant associated protein pulmonary 2 antibody
Surfactant protein c antibody
Surfactant proteolipid SPL-pVal antibody
Surfactant pulmonary associated protein C antibody
Western blot - Anti-Prosurfactant Protein C antibody - Aminoterminal end (ab170699)
Anti-Prosurfactant Protein C antibody - Aminoterminal end (ab170699) + Mouse liver tissue lysate at 35 µg
Predicted band size: 21 kDa
Immunocytochemistry/ Immunofluorescence - Anti-Prosurfactant Protein C antibody - Aminoterminal end (ab170699)
Immunocytochemsitry/Immunofluorescence analysis of HepG2 cells labeling Prosurfactant Protein C (green) using ab170699. An Alexa Fluor® 488-conjugated goat anti-rabbit lgG was used as the secondary antibody. Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red).