Anti-Proteasome 19S S5A/ASF antibody (ab18512)
Key features and details
- Rabbit polyclonal to Proteasome 19S S5A/ASF
- Suitable for: WB
- Reacts with: Drosophila melanogaster
- Isotype: IgG
Overview
-
Product name
Anti-Proteasome 19S S5A/ASF antibody
See all Proteasome 19S S5A/ASF primary antibodies -
Description
Rabbit polyclonal to Proteasome 19S S5A/ASF -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Drosophila melanogaster -
Immunogen
Full length protein corresponding to Drosophila melanogaster Proteasome 19S S5A/ASF.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
-
Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab18512 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/1000. Predicted molecular weight: 41 kDa.
|
Notes |
---|
WB
1/1000. Predicted molecular weight: 41 kDa. |
Target
-
Function
Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion. -
Sequence similarities
Belongs to the proteasome subunit S5A family.
Contains 2 UIM (ubiquitin-interacting motif) repeats.
Contains 1 VWFA domain. -
Domain
The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. - Information by UniProt
-
Database links
- Entrez Gene: 40388 Drosophila melanogaster
- SwissProt: P55035 Drosophila melanogaster
- Unigene: 23542 Drosophila melanogaster
-
Alternative names
- 26S protease subunit S5a antibody
- 26S proteasome non ATPase regulatory subunit 4 antibody
- 26S proteasome non-ATPase regulatory subunit 4 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (3)
ab18512 has been referenced in 3 publications.
- Blount JR et al. Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila. Sci Rep 8:8513 (2018). PubMed: 29855490
- Jiang Y et al. Discovery of microarray-identified genes associated with the progression of cervical intraepithelial neoplasia. Int J Clin Exp Pathol 11:5667-5681 (2018). PubMed: 31949653
- Vernace VA et al. Aging and regulated protein degradation: who has the UPPer hand? Aging Cell 6:599-606 (2007). WB ; Drosophila melanogaster . PubMed: 17681036