Recombinant Anti-Protein S antibody [EPSISR9] (ab133730)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Protein S antibody [EPSISR9]
See all Protein S primary antibodies -
Description
Rabbit monoclonal [EPSISR9] to Protein S -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC,IHC-P or IP -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide within Human Protein S aa 550-650. The exact sequence is proprietary.
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Positive control
- Human plasma lysate
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General notes
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.
This product is a recombinant rabbit monoclonal antibody.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPSISR9 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab133730 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000 - 1/10000. Predicted molecular weight: 75 kDa. |
Target
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Function
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. -
Tissue specificity
Plasma. -
Involvement in disease
Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. -
Sequence similarities
Contains 4 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 2 laminin G-like domains. -
Post-translational
modificationsThe iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 5627 Human
- Omim: 176880 Human
- SwissProt: P07225 Human
- Unigene: 64016 Human
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Alternative names
- Preproprotein S antibody
- Propiece of latent protein S antibody
- PROS 1 antibody
see all
Images
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![Western blot - Anti-Protein S antibody [EPSISR9] (ab133730)](https://www.abcam.com/ps/products/133/ab133730/Images/ab133730-147782-anti-protein-s-antibody-epsisr9-western-blot.jpg)
Western blot - Anti-Protein S antibody [EPSISR9] (ab133730)Anti-Protein S antibody [EPSISR9] (ab133730) at 1/1000 dilution + Human plasma lysate at 10 µg
Secondary
HRP labelled Goat anti-Rabbit IgG at 1/2000 dilution
Predicted band size: 75 kDa
Protocols
References
ab133730 has not yet been referenced specifically in any publications.
