Key features and details
- Potent, selective CaV3.1 channel blocker. Inhibits NaV1 and KV2.1 channels.
- CAS Number:
- Purity: > 98%
- Soluble in water
- Form / State: Solid
- Source: Thrixopelma pruriens
Product nameProTx-I, CaV3.1 channel blocker. Inhibits NaV1 and KV2.1 channels.
DescriptionPotent, selective CaV3.1 channel blocker. Inhibits NaV1 and KV2.1 channels.
Biological descriptionPotent, selective CaV3.1 channel blocker (IC50 values are 0.2 and 32 μM for CaV3.1 and CaV3.2 respectively). Reversibly inhibits all NaV1 subtypes by modifying gating kinetics similar to ProTx-II (Asc 1880). Blocks KV2.1 channels. Shows proliferative effects.
SequenceECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS (Modifications: Disulfide bonds: 2-16, 9-21, 15-28)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141863 has not yet been referenced specifically in any publications.