Key features and details
- Rabbit polyclonal to PROX1
- Suitable for: IHC-Fr
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-PROX1 antibody
See all PROX1 primary antibodies
DescriptionRabbit polyclonal to PROX1
Tested applicationsSuitable for: IHC-Frmore details
Species reactivityReacts with: Mouse, Human
Recombinant fragment corresponding to Human PROX1 (C terminal). (Homeo domain and Prospero domain)
Database link: Q92786
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab101851 in the following tested applications.
|IHC-Fr||Use at an assay dependent concentration.|
FunctionTranscription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
Tissue specificityMost actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
Sequence similaritiesBelongs to the Prospero homeobox family.
Contains 1 Prospero-type homeobox DNA-binding domain.
DomainThe prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
Cellular localizationNucleus. RORG promotes its nuclear localization.
- Information by UniProt
FormProx1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently. Sox18 directly activates Prox1 transcription by binding to its proximal promoter.
- Homeobox prospero like protein antibody
- Homeobox prospero like protein PROX1 antibody
- Homeobox prospero-like protein PROX1 antibody
ab101851 has been referenced in 7 publications.
- Michalaki E et al. Perpendicular alignment of lymphatic endothelial cells in response to spatial gradients in wall shear stress. Commun Biol 3:57 (2020). PubMed: 32029852
- Allard B et al. Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis. Oncoimmunology 8:1601481 (2019). PubMed: 31413909
- Jaeger BN et al. A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons. Nat Commun 9:3084 (2018). PubMed: 30082781
- Pichol-Thievend C et al. A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development. Development 145:N/A (2018). PubMed: 29773646
- Li G et al. Generation of Retinal Organoids with Mature Rods and Cones from Urine-Derived Human Induced Pluripotent Stem Cells. Stem Cells Int 2018:4968658 (2018). PubMed: 30008752
- Hou H et al. BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus. Stem Cell Reports 9:217-230 (2017). IHC-Fr ; Mouse . PubMed: 28669600
- Yu TS et al. Adult newborn neurons interfere with fear discrimination in a protocol-dependent manner. Brain Behav 7:e00796 (2017). PubMed: 28948089