Overview

  • Product name

  • Description

    Rabbit polyclonal to PROX1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC - Wholemountmore details
  • Species reactivity

    Reacts with: Zebrafish
  • Immunogen

    Recombinant fragment within Zebrafish PROX1 aa 239-487 (internal sequence). The exact sequence is proprietary.
    Database link: 30679

  • Positive control

    • Zebrafish embryo

Properties

Applications

Our Abpromise guarantee covers the use of ab209849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC - Wholemount 1/100 - 1/500.

Target

  • Function

    Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • Tissue specificity

    Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • Sequence similarities

    Belongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • Domain

    The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Cellular localization

    Nucleus. RORG promotes its nuclear localization.
  • Information by UniProt
  • Database links

    • Form

      Prox1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently. Sox18 directly activates Prox1 transcription by binding to its proximal promoter.
    • Alternative names

      • Homeobox prospero like protein antibody
      • Homeobox prospero like protein PROX1 antibody
      • Homeobox prospero-like protein PROX1 antibody
      • Prospero homeobox 1 antibody
      • Prospero homeobox protein 1 antibody
      • Prospero related homeobox 1 antibody
      • prospero-related homeobox gene 1 antibody
      • PROX 1 antibody
      • PROX-1 antibody
      • PROX1 antibody
      • PROX1_HUMAN antibody
      • zgc:111888 antibody
      see all

    Images

    • Wholemount immunohistochemical analysis of 2-day post-fertilization zebrafish embryo tissue, labeling PROX1 using ab209849 at a 1/100 dilution.

    • Wholemount immunohistochemical analysis of paraformaldehyde-fixed zebrafish embryos, labeling PROX1 using ab209849 at a 1/200 dilution.

    References

    This product has been referenced in:

    • Shi J  et al. Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish. Proc Natl Acad Sci U S A 114:11950-11955 (2017). Read more (PubMed: 29078404) »
    See 1 Publication for this product

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