Proxymetacaine hydrochloride, voltage-gated sodium channel protein blocker (ab143687)

Overview

  • Product name

    Proxymetacaine hydrochloride, voltage-gated sodium channel protein blocker
  • Description

    Neuron voltage-gated sodium channel protein blocker
  • Biological description

    Neuron voltage-gated sodium channel protein blocker (IC50 = 3.4 mM). Induces dose-related spinal blockades of motor function, proprioception and nociception. Shows anesthetic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    5875-06-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride
  • Molecular weight

    330.85
  • Molecular formula

    C16H26N2O3.HCl
  • PubChem identifier

    517321
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 75 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hung CH  et al. The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats. Anesth Analg 110:238-42 (2010). Read more (PubMed: 19897799) »
  • Wollensak G & Iomdina E Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 35:540-6 (2009). Read more (PubMed: 19251149) »
  • Hung CH  et al. Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett 454:249-53 (2009). Read more (PubMed: 19429093) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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