Overview

  • Product name

  • Description

    Rabbit polyclonal to PRPF31
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human PRPF31 aa 222-465. The exact sequence is proprietary.
    Database link: Q8WWY3

  • Positive control

    • A549, H1299 and HCT116 cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab184127 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 55 kDa.

Target

  • Function

    Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.
  • Tissue specificity

    Ubiquitously expressed.
  • Involvement in disease

    Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the PRP31 family.
    Contains 1 Nop domain.
  • Domain

    Interacts with the snRNP via the Nop domain.
    The coiled coil domain is formed by two non-contiguous helices.
  • Cellular localization

    Nucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp566J153 antibody
    • hPrp 31 antibody
    • hPrp31 antibody
    • NY BR 99 antibody
    • Pre mRNA processing factor 31 antibody
    • Pre mRNA processing factor 31 homolog (yeast) antibody
    • Pre mRNA processing factor 31 homolog antibody
    • Pre-mRNA-processing factor 31 antibody
    • Precursor mRNA-processing factor 31, S. cerevisiae, homolog of antibody
    • Protein 61K antibody
    • PRP 31 antibody
    • PRP31 antibody
    • PRP31 pre mRNA processing factor 31 homolog (yeast) antibody
    • PRP31 pre mRNA processing factor 31 homolog antibody
    • PRP31_HUMAN antibody
    • PRPF 31 antibody
    • prpf31 antibody
    • RP 11 antibody
    • RP11 antibody
    • Serologically defined breast cancer antigen NY BR 99 antibody
    • Serologically defined breast cancer antigen NY-BR-99 antibody
    • SNRNP61 antibody
    • U4/U6 small nuclear ribonucleoprotein Prp31 antibody
    • U4/U6 snRNP 61 kDa protein antibody
    see all

Images

  • All lanes : Anti-PRPF31 antibody (ab184127) at 1/1000 dilution

    Lane 1 : A549 cell lysate
    Lane 2 : H1299 cell lysate
    Lane 3 : HCT116 whole cell lysate

    Predicted band size: 55 kDa



    7.5 % SDS-PAGE

References

ab184127 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab184127.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up