• Product name
  • Description
    Goat polyclonal to PRPF31
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide: LKVKGEKSGLMST, corresponding to C terminal amino acids 487-499 of Human PRPF31.

  • Positive control
    • A431 lysate.
  • General notes
    Principal Names - PRPF31; PRP31 pre-mRNA processing factor 31 homolog (yeast); RP11; PRP31; NY-BR-99; DKFZp566J153; pre-mRNA processing factor 31 homolog (yeast). Official Gene Symbol - PRPF31. GenBank Accession Number – NP_056444. LocusLink ID - 26121.



Our Abpromise guarantee covers the use of ab2467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 62 kDa (predicted molecular weight: 55 kDa).Can be blocked with Human PRPF31 peptide (ab22909).


  • Function
    Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.
  • Tissue specificity
    Ubiquitously expressed.
  • Involvement in disease
    Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.
  • Sequence similarities
    Belongs to the PRP31 family.
    Contains 1 Nop domain.
  • Domain
    Interacts with the snRNP via the Nop domain.
    The coiled coil domain is formed by two non-contiguous helices.
  • Cellular localization
    Nucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp566J153 antibody
    • hPrp 31 antibody
    • hPrp31 antibody
    • NY BR 99 antibody
    • Pre mRNA processing factor 31 antibody
    • Pre mRNA processing factor 31 homolog (yeast) antibody
    • Pre mRNA processing factor 31 homolog antibody
    • Pre-mRNA-processing factor 31 antibody
    • Precursor mRNA-processing factor 31, S. cerevisiae, homolog of antibody
    • Protein 61K antibody
    • PRP 31 antibody
    • PRP31 antibody
    • PRP31 pre mRNA processing factor 31 homolog (yeast) antibody
    • PRP31 pre mRNA processing factor 31 homolog antibody
    • PRP31_HUMAN antibody
    • PRPF 31 antibody
    • prpf31 antibody
    • RP 11 antibody
    • RP11 antibody
    • Serologically defined breast cancer antigen NY BR 99 antibody
    • Serologically defined breast cancer antigen NY-BR-99 antibody
    • SNRNP61 antibody
    • U4/U6 small nuclear ribonucleoprotein Prp31 antibody
    • U4/U6 snRNP 61 kDa protein antibody
    see all


ab2467 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your enquiry. I am sorry to hear that you have been having difficulties with this antibody. It is a good selling antibody that we have received very few complaints about. You are performing an approach that I would largely recommen...

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I'm sorry to hear you are experiencing problems with ab2467. I have asked our laboratory and we have not received any other complaints about this antibody, in fact you received the same master stock in each order. Our policy is to replace or refund ...

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