Overview

  • Product name

    PRT 4165, Bmi1/Ring1A inhibitor
  • Description

    Bmi1/Ring1A inhibitor
  • Biological description

    Bmi1/Ring1A inhibitor (IC50 = 3.9 μM). Prevents ubiquitination and drug-induced degradation of topoisomerase. Blocks PRC1-mediated histone H2A ubiquitination in vivo.
  • Purity

    > 98%
  • CAS Number

    31083-55-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(Pyridin-3-ylmethylidene)indene-1,3-dione
  • Molecular weight

    235.24
  • Molecular formula

    C15H9NO2
  • PubChem identifier

    207893
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in 1 eq. HCl to 5 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)C(=O)C(=CC3=CN=CC=C3)C2=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ismail IH  et al. A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem 288:26944-54 (2013). Read more (PubMed: 23902761) »

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