PS48, Allosteric phosphoinositide-dependent protein kinase-1 (PDK1) agonist (ab142133)

Overview

  • Product name

    PS48, Allosteric phosphoinositide-dependent protein kinase-1 (PDK1) agonist
  • Description

    Allosteric phosphoinositide-dependent protein kinase-1 (PDK1) agonist
  • Biological description

    Allosteric PDK1 activator. Stimulates PI3-kinase and phosphorylates AKT. Binds to the PIF pocket in the small lobe of PDK1. Shows developmental effects in vivo.
  • Purity

    > 95%
  • CAS Number

    1180678-32-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid
  • Molecular weight

    286.75
  • Molecular formula

    C17H15ClO2
  • PubChem identifier

    44141940
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sadowsky JD  et al. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc Natl Acad Sci U S A 108:6056-61 (2011). Read more (PubMed: 21430264) »
  • Williams G Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct Biol 10:11 (2010). Read more (PubMed: 20500829) »
  • Stroba A  et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J Med Chem 52:4683-93 (2009). Read more (PubMed: 19606904) »
  • Hindie V  et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol 5:758-64 (2009). Read more (PubMed: 19718043) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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