Overview

  • Product name

    PS48 (DMSO solution), PDK1 activator
  • Description

    Allosteric PDK1 activator
  • Biological description

    Allosteric PDK1 activator. Stimulates PI3-kinase and phosphorylates AKT. Binds to the PIF pocket in the small lobe of PDK1. Shows developmental effects in vivo.

    Also available as a solid (ab142133).
  • Purity

    > 95%
  • CAS Number

    1180678-32-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Spate LD  et al. PS48 can replace bovine serum albumin in pig embryo culture medium, and improve in vitro embryo development by phosphorylating AKT. Mol Reprod Dev 82:315-20 (2015). Read more (PubMed: 25776657) »
  • Williams G Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct Biol 10:11 (2010). Read more (PubMed: 20500829) »
  • Hindie V  et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol 5:758-64 (2009). Read more (PubMed: 19718043) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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