Overview

  • Product name
    Psalmotoxin-1, ASIC1a blocker
  • Description
    Potent, selective ASIC1a blocker
  • Alternative names
    • PcTx1
  • Biological description
    Potent, selective acid sensing (proton gated) ion channel 1a (ASIC1a) blocker. Inhibits cation currents mediated by ASICs (IC50 = 36 pM). Displays highly potent analgesic properties against neuropathic pain.
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Mazzuca M  et al. A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat Neurosci 10:943-5 (2007). Read more (PubMed: 17632507) »
  • Salinas M  et al. The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J Physiol 570:339-54 (2006). Read more (PubMed: 16284080) »
  • Escoubas P  et al. Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci 12:1332-43 (2003). Read more (PubMed: 12824480) »
See all 4 Publications for this product

Customer reviews and Q&As

Answer

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I can confirm that ab120483 is a synthetic peptide.

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