Overview

  • Product name

    Psammaplin A, DNA methyltransferase
  • Description

    Potent DNA methyltransferase and HDAC inhibitor
  • Biological description

    Potent DNA methyltransferase and HDAC inhibitor (IC50 = 3 nM, HDAC). Inhibits Topoisomerase II (IC50 = 75 μM). Inhibits proliferation (IC50 = 1 μM, HeLa cells). Inhibits angiogenesis. Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    110659-91-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kim HJ  et al. DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity. Radiat Oncol 7:39 (2012). Read more (PubMed: 22429326) »
  • Kim DH  et al. Psammaplin A is a natural prodrug that inhibits class I histone deacetylase. Exp Mol Med 39:47-55 (2007). Read more (PubMed: 17334228) »
  • Kim D  et al. Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase II and is cytotoxic to cancer cells. Anticancer Res 19:4085-90 (0). Read more (PubMed: 10628358) »

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