Overview

  • Product name

    Anti-PSCA antibody, prediluted
    See all PSCA primary antibodies
  • Description

    Rabbit polyclonal to PSCA, prediluted
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human PSCA (extracellular). The exact sequence is proprietary.
    Database link: O43653

  • Positive control

    • Bladder carcinoma and Prostate carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab15169 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Relevance

    PSCA (Prostate Stem Cell antigen) is a cell surface antigen, which is overexpressed in ~40% of primary prostate cancers and in as many as 100% of metastatic ones. PSCA is also overexpressed in a majority of transitional cell and pancreatic carcinomas. Antibody directed against PSCA inhibits tumorigenesis, slows tumor growth, prolongs survival and prevents metastasis in a preclinical zenograft model indicating that PSCA may have utility as a prognostic marker and/or therapeutic target in prostate cancer.
  • Cellular localization

    Cell membrane; Lipid-anchor, GPI-anchor.
  • Database links

  • Alternative names

    • PRO 232 antibody
    • PRO232 antibody
    • Prostate stem cell antigen antibody

Images

  • ab15169 staining PSCA in human breast carcinoma by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

References

This product has been referenced in:

  • Taeb J  et al. Expression of prostate stem cell antigen (PSCA) in prostate cancer: A tissue microarray study of Iranian patients. Pathol Res Pract N/A:N/A (2013). IHC-P ; Human . Read more (PubMed: 24183365) »
See 1 Publication for this product

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