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Anti-PSD93 antibody (ab2930)

  • Datasheet
  • SDS
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Immunocytochemistry/ Immunofluorescence - Anti-PSD93 antibody (ab2930)
  • Western blot - Anti-PSD93 antibody (ab2930)
  • Immunocytochemistry/ Immunofluorescence - Anti-PSD93 antibody (ab2930)

Key features and details

  • Rabbit polyclonal to PSD93
  • Suitable for: WB, ICC/IF
  • Reacts with: Rat
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-PSD93 antibody
    See all PSD93 primary antibodies
  • Description

    Rabbit polyclonal to PSD93
  • Host species

    Rabbit
  • Specificity

    Detects Post Synaptic Density 93 (PSD 93) from rat tissues. This antibody does not detect other synapse-associated protein family members.
  • Tested Applications & Species

    Application Species
    ICC/IF
    Rat
    WB
    Rat
    See all applications and species data
  • Immunogen

    Synthetic peptide corresponding to Rat PSD93 aa 352-366.
    Sequence:

    NKLCDKPASPRHYSP


    (Peptide available as ab5840)
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Primary antibody notes

    Post Synaptic Density 93 (PSD 93), also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD 93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD 93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. PSD 93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD 93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD 93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD 93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmission
    • Intracellular Signaling
    • Adapters
    • Neuroscience
    • Cell Type Marker
    • Neuron marker
    • Synapse marker
    • Neuroscience
    • Sensory System
    • Somatosensory system
    • Nociception

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Immunizing Peptide (Blocking)

    • PSD93 peptide (ab5840)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab2930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC/IF
Rat
WB
Rat
All applications
Mouse
Human
Application Abreviews Notes
WB
Use a concentration of 3 µg/ml. Detects a band of approximately 110 kDa.Can be blocked with PSD93 peptide (ab5840).
ICC/IF
Use a concentration of 1 µg/ml.
Notes
WB
Use a concentration of 3 µg/ml. Detects a band of approximately 110 kDa.Can be blocked with PSD93 peptide (ab5840).
ICC/IF
Use a concentration of 1 µg/ml.

Target

  • Function

    Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
  • Sequence similarities

    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 3 PDZ (DHR) domains.
    Contains 1 SH3 domain.
  • Domain

    An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
  • Post-translational
    modifications

    Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
  • Cellular localization

    Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Concentrated in soma and postsynaptic density of a subset of neurons.
  • Target information above from: UniProt accession Q15700 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 1740 Human
    • Entrez Gene: 23859 Mouse
    • Entrez Gene: 64053 Rat
    • Omim: 603583 Human
    • SwissProt: Q15700 Human
    • SwissProt: Q91XM9 Mouse
    • SwissProt: Q63622 Rat
    • Unigene: 367656 Human
    • Unigene: 147213 Mouse
    • Unigene: 257035 Mouse
    • Unigene: 202966 Rat
    see all
  • Alternative names

    • Channel associated protein of synapse 110 antibody
    • Channel associated protein of synapses 110kD antibody
    • Channel-associated protein of synapse-110 antibody
    • Chapsyn 110 antibody
    • Chapsyn-110 antibody
    • Chapsyn110 antibody
    • Discs, large homolog 2 (Drosophila) antibody
    • Disks large homolog 2 antibody
    • DKFZp781D1854 antibody
    • DKFZp781E0954 antibody
    • Dlg 2 antibody
    • dlg2 antibody
    • DLG2_HUMAN antibody
    • Dlgh 2 antibody
    • Dlgh2 antibody
    • FLJ37266 antibody
    • Gm1197 antibody
    • MGC131811 antibody
    • Postsynaptic density protein PSD 93 antibody
    • Postsynaptic density protein PSD-93 antibody
    • Postsynaptic density protein PSD93 antibody
    • PSD 93 antibody
    • PSD93 antibody
    see all

Images

  • Immunocytochemistry/ Immunofluorescence - Anti-PSD93 antibody (ab2930)
    Immunocytochemistry/ Immunofluorescence - Anti-PSD93 antibody (ab2930)

    Immunolocalization of PSD-93 in rat cerebellum using ab2930.

  • Western blot - Anti-PSD93 antibody (ab2930)
    Western blot - Anti-PSD93 antibody (ab2930)

     Western blot of PSD-93 on rat brain extract using ab2930.

  • Immunocytochemistry/ Immunofluorescence - Anti-PSD93 antibody (ab2930)
    Immunocytochemistry/ Immunofluorescence - Anti-PSD93 antibody (ab2930)
    ICC/IF image of ab2930 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab2930, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Protocols

  • Immunohistochemistry protocols
  • Immunocytochemistry & immunofluorescence protocols
  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (4)

Publishing research using ab2930? Please let us know so that we can cite the reference in this datasheet.

ab2930 has been referenced in 4 publications.

  • Mahaman YAR  et al. Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments. J Alzheimers Dis 63:1141-1159 (2018). PubMed: 29710724
  • Li XH  et al. Glycation exacerbates the neuronal toxicity of ß-amyloid. Cell Death Dis 4:e673 (2013). Mouse . PubMed: 23764854
  • Sun Q & Turrigiano GG PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down. J Neurosci 31:6800-8 (2011). ICC/IF ; Rat . PubMed: 21543610
  • Sahab ZJ  et al. Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26. J Cancer 1:14-22 (2010). WB ; Human . PubMed: 20842219

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