Overview

  • Product name
    PSD93 peptide

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and PSD93, catalog ab2930. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • Channel associated protein of synapse 110
    • Channel associated protein of synapses 110kD
    • Channel-associated protein of synapse-110
    • Chapsyn 110
    • Chapsyn-110
    • Chapsyn110
    • Discs, large homolog 2 (Drosophila)
    • Disks large homolog 2
    • DKFZp781D1854
    • DKFZp781E0954
    • Dlg 2
    • dlg2
    • DLG2_HUMAN
    • Dlgh 2
    • Dlgh2
    • FLJ37266
    • Gm1197
    • MGC131811
    • Postsynaptic density protein PSD 93
    • Postsynaptic density protein PSD-93
    • Postsynaptic density protein PSD93
    • PSD 93
    • PSD93
    see all
  • Function
    Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
  • Sequence similarities
    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 3 PDZ (DHR) domains.
    Contains 1 SH3 domain.
  • Domain
    An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
  • Post-translational
    modifications
    Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
  • Cellular localization
    Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Concentrated in soma and postsynaptic density of a subset of neurons.
  • Information by UniProt

References

ab5840 has not yet been referenced specifically in any publications.

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