Recombinant
RabMAb

Recombinant Anti-PSD95 (phospho T19) antibody [EPR2619(2)] - BSA and Azide free (ab249719)

Overview

  • Product name
    Anti-PSD95 (phospho T19) antibody [EPR2619(2)] - BSA and Azide free
    See all PSD95 primary antibodies
  • Description
    Rabbit monoclonal [EPR2619(2)] to PSD95 (phospho T19) - BSA and Azide free
  • Host species
    Rabbit
  • Specificity

    This antibody only detects PSD95 phosphorylated at Threonine 19.

  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human PSD95 aa 1-100 (phospho T19) (Cysteine residue). The exact sequence is proprietary.
    Database link: P78352

  • General notes

    ab249719 is a PBS-only buffer format of ab172628. Please refer to ab172628 for recommended dilutions, protocols, and image data.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab249719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 80 kDa.
IP Use at an assay dependent concentration.
  • Application notes
    Is unsuitable for ICC or IHC-P.
  • Target

    • Function
      Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
    • Tissue specificity
      Brain.
    • Sequence similarities
      Belongs to the MAGUK family.
      Contains 1 guanylate kinase-like domain.
      Contains 3 PDZ (DHR) domains.
      Contains 1 SH3 domain.
    • Domain
      The PDZ domain 3 mediates interaction with ADR1B.
      The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.
    • Post-translational
      modifications
      Palmitoylation of isoform 1 is required for targeting to postsynaptic density.
    • Cellular localization
      Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • Discs large homolog 4 antibody
      • Disks large homolog 4 antibody
      • DLG 4 antibody
      • Dlg4 antibody
      • DLG4_HUMAN antibody
      • FLJ97752 antibody
      • FLJ98574 antibody
      • Human post synaptic density protein 95 antibody
      • Post synaptic density protein 95 antibody
      • Postsynaptic density protein 95 antibody
      • PSD 95 antibody
      • PSD-95 antibody
      • PSD95 antibody
      • SAP 90 antibody
      • SAP-90 antibody
      • SAP90 antibody
      • Synapse associated protein 90 antibody
      • Synapse-associated protein 90 antibody
      • Tax interaction protein 15 antibody
      see all

    References

    ab249719 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab249719.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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