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    psma7hspc-antibody-ab97564.pdf

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Cell Biology Proteolysis / Ubiquitin Proteasome / Ubiquitin Proteasome
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Anti-PSMA7/HSPC antibody (ab97564)

  • Datasheet
  • SDS
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Western blot - Anti-PSMA7/HSPC antibody (ab97564)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMA7/HSPC antibody (ab97564)

Key features and details

  • Rabbit polyclonal to PSMA7/HSPC
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Secondary
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
Protein
Product image
Recombinant Human PSMA7/HSPC protein (ab81381)

View more associated products

Overview

  • Product name

    Anti-PSMA7/HSPC antibody
    See all PSMA7/HSPC primary antibodies
  • Description

    Rabbit polyclonal to PSMA7/HSPC
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Zebrafish
  • Immunogen

    Recombinant fragment corresponding to Human PSMA7/HSPC aa 10-217.
    Database link: O14818

  • Positive control

    • WB: 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lysates IHC-P: CL15 xenograft
  • General notes

     This product was previously labelled as PSMA7

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteasome / Ubiquitin
    • Proteasome

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa nuclear extract lysate (ab14655)
    • HepG2 cytoplasmic extract lysate (ab14659)
    • HepG2 nuclear extract lysate (ab14660)
    • HeLa whole cell lysate (ab29545)
    • Raji whole cell lysate (ab30124)
    • A431 whole cell lysate (ab7909)
    • MOLT4 whole cell lysate (ab7912)
  • Recombinant Protein

    • Recombinant Human PSMA7/HSPC protein (ab81381)

Applications

Our Abpromise guarantee covers the use of ab97564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
  • Sequence similarities

    Belongs to the peptidase T1A family.
  • Post-translational
    modifications

    Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Target information above from: UniProt accession O14818 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 505050 Cow
    • Entrez Gene: 5688 Human
    • Entrez Gene: 26444 Mouse
    • Entrez Gene: 29674 Rat
    • Omim: 606607 Human
    • SwissProt: Q3ZBG0 Cow
    • SwissProt: O14818 Human
    • SwissProt: Q9Z2U0 Mouse
    • SwissProt: P48004 Rat
    • Unigene: 233952 Human
    • Unigene: 21728 Mouse
    • Unigene: 105784 Rat
    see all
  • Alternative names

    • C6 antibody
    • HSPC antibody
    • MGC3755 antibody
    • OTTHUMP00000031449 antibody
    • OTTHUMP00000031450 antibody
    • OTTHUMP00000031453 antibody
    • Proteasome (prosome macropain) subunit alpha type 7 antibody
    • Proteasome alpha 7 subunit antibody
    • Proteasome subunit alpha 4 antibody
    • Proteasome subunit alpha type 7 antibody
    • Proteasome subunit alpha type-7 antibody
    • Proteasome subunit RC6 1 antibody
    • Proteasome subunit RC6-1 antibody
    • Proteasome subunit XAPC7 antibody
    • PSA7_HUMAN antibody
    • PSMA 7 antibody
    • PSMA7 antibody
    • RC6 1 antibody
    • XAPC7 antibody
    see all

Images

  • Western blot - Anti-PSMA7/HSPC antibody (ab97564)
    Western blot - Anti-PSMA7/HSPC antibody (ab97564)
    All lanes : Anti-PSMA7/HSPC antibody (ab97564) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : HeLa whole cell lysate
    Lane 4 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 28 kDa



    12% SDS PAGE
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMA7/HSPC antibody (ab97564)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMA7/HSPC antibody (ab97564)

    ab97564, at a 1/100 dilution, staining PSMA7/HSPC in a paraffin-embedded CL15 xenograft by Immunohistochemical analysis.

Protocols

  • Western blot protocols
  • Immunohistochemistry protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab97564? Please let us know so that we can cite the reference in this datasheet.

    ab97564 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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