Overview

  • Product name

    Psoralen (Ficusin), DNA synthesis inhibitor 
  • Description

    Covalently cross-links DNA to produce toxic lesions
  • Alternative names

    • Ficusin
  • Biological description

    Covalently cross-links DNA to produce toxic lesions. Activated by UV light at wavelengths 320 to 400 nm. Photosensitizing, cross-linking and anthelmintic agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    66-97-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Furo[3,2-g]chromen-7-one
  • Molecular weight

    186.16
  • Molecular formula

    C11H6O3
  • PubChem identifier

    6199
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=O)OC2=CC3=C(C=CO3)C=C21
  • Source

    Psoralea sp.

  • Research areas

References

This product has been referenced in:

  • Vare D  et al. DNA interstrand crosslinks induce a potent replication block followed by formation and repair of double strand breaks in intact mammalian cells. DNA Repair (Amst) 11:976-85 (2012). Read more (PubMed: 23099010) »
  • Smith LA  et al. Bypass of a psoralen DNA interstrand cross-link by DNA polymerases ß, ?, and ? in vitro. Biochemistry 51:8931-8 (2012). Read more (PubMed: 23106263) »
  • Laskin JD Cellular and molecular mechanisms in photochemical sensitization: studies on the mechanism of action of psoralens. Food Chem Toxicol 32:119-27 (1994). Read more (PubMed: 8132171) »

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