Overview

  • Product name

  • Description

    Goat polyclonal to PSPH
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human PSPH aa 202-215 (C terminal) (Cysteine residue).
    Sequence:

    RQQVKDNAKWYITD


    Database link: NP_004568.2

  • Positive control

    • Human brain (hippocampus) and mouse brain lysates
  • General notes

    Previously labelled as Phosphoserine phosphatase.

Properties

Applications

Our Abpromise guarantee covers the use of ab87641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.05 - 1 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 25 kDa).

Target

  • Function

    Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
  • Pathway

    Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
  • Involvement in disease

    Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.
  • Sequence similarities

    Belongs to the SerB family.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC 3.1.3.3 antibody
    • L 3 phosphoserine phosphatase antibody
    • L-3-phosphoserine phosphatase antibody
    • O phosphoserine phosphohydrolase antibody
    • O-phosphoserine phosphohydrolase antibody
    • Phosphoserine phosphatase antibody
    • Phosphoserine phosphatase deficiency, included antibody
    • PSP antibody
    • PSPase antibody
    • Psph antibody
    • PSPHD antibody
    • SERB_HUMAN antibody
    see all

Images

  • Anti-PSPH antibody (ab87641) at 0.05 µg/ml + mouse brain lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 25 kDa
    Observed band size: ~26 kDa
    why is the actual band size different from the predicted?


    Exposure time: 1 hour

References

ab87641 has not yet been referenced specifically in any publications.

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