Overview

  • Product name

    Anti-PSPN antibody
  • Description

    Rabbit polyclonal to PSPN
  • Host species

    Rabbit
  • Specificity

    ab198256 detects endogenous levels of total PSPN protein.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human PSPN (internal sequence). The exact sequence is proprietary.
    Database link: O60542

  • Positive control

    • paraffin-embedded Human colon cancer and ovarian cancer tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab198256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Relevance

    PSPN is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. PSPN has a similar structure to other family members, glial cell line-derived neurotrophic factor, Artemin and neurturin. All these proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. PSPN signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken and was later shown to be the preferential binding subunit for PSPN. In contrast to GDNF and Neurturin, PSPN does not support survival of peripheral neurons.
  • Cellular localization

    Secreted
  • Database links

  • Alternative names

    • Persephin antibody
    • PSP antibody
    • PSPN antibody

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling PSPN using ab198256 at 1/25 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue labeling PSPN using ab198256 at 1/25 dilution.

References

ab198256 has not yet been referenced specifically in any publications.

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