Anti-PTCH2 antibody (ab151775)
Key features and details
- Rabbit polyclonal to PTCH2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PTCH2 antibody
See all PTCH2 primary antibodies -
Description
Rabbit polyclonal to PTCH2 -
Host species
Rabbit -
Specificity
No cross reactivity with other proteins. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse
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Immunogen
A synthetic peptide corresponding to C terminal residues of Human PTCH2 (UniProt: Q9Y6C5).
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Positive control
- HeLa cell lysate.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
Constituents: 0.1% Dibasic monohydrogen sodium phosphate, 0.45% Sodium chloride, 2.5% BSA -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab151775 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 131 kDa. |
Target
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Function
May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). -
Involvement in disease
Defects in PTCH2 are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome).
Defects in PTCH2 are a cause of sporadic basal cell carcinoma (BCC) [MIM:605462]. -
Sequence similarities
Belongs to the patched family.
Contains 1 SSD (sterol-sensing) domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 8643 Human
- Entrez Gene: 19207 Mouse
- Omim: 603673 Human
- SwissProt: Q9Y6C5 Human
- SwissProt: O35595 Mouse
- Unigene: 591497 Human
- Unigene: 287037 Mouse
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Alternative names
- patched (Drosophila) homolog 2 antibody
- patched homolog 2 (Drosophila) antibody
- Protein patched homolog 2 antibody
see all
Images
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Western blot - Anti-PTCH2 antibody (ab151775)Anti-PTCH2 antibody (ab151775) at 0.5 µg/ml + HeLa cell lysate
Predicted band size: 131 kDa
References (1)
ab151775 has been referenced in 1 publication.
- Zuo Q et al. Interaction of the primordial germ cell-specific protein C2EIP with PTCH2 directs differentiation of embryonic stem cells via HH signaling activation. Cell Death Dis 9:497 (2018). PubMed: 29703892
