Anti-PTGER3 antibody - Cytoplasmic domain (ab189131)
Key features and details
- Rabbit polyclonal to PTGER3 - Cytoplasmic domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PTGER3 antibody - Cytoplasmic domain
See all PTGER3 primary antibodies -
Description
Rabbit polyclonal to PTGER3 - Cytoplasmic domain -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Monkey, Gorilla, Bat -
Immunogen
Synthetic peptide within Human PTGER3. The exact sequence is proprietary. The synthetic peptide corresponds to 17 amino acids from the first cytoplasmic domain.
Database link: P43115 -
Positive control
- Human breast tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab189131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 1 - 3 µg/ml.
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Notes |
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IHC-P
Use a concentration of 1 - 3 µg/ml. |
Target
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Function
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems. -
Tissue specificity
Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 102442487 Bat
- Entrez Gene: 101130056 Gorilla
- Entrez Gene: 5733 Human
- Entrez Gene: 19218 Mouse
- Omim: 176806 Human
- SwissProt: P43115 Human
- SwissProt: P30557 Mouse
- Unigene: 445000 Human
see all -
Alternative names
- EP 3 antibody
- EP3 antibody
- EP3 I antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab189131 has been referenced in 2 publications.
- Ye Y et al. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect 7:749-761 (2018). PubMed: 29700097
- Heidegger H et al. The Prostaglandin EP3 Receptor Is an Independent Negative Prognostic Factor for Cervical Cancer Patients. Int J Mol Sci 18:N/A (2017). PubMed: 28753926