Key features and details
- Rabbit polyclonal to PTGER3 - Cytoplasmic domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PTGER3 antibody - Cytoplasmic domain
See all PTGER3 primary antibodies
DescriptionRabbit polyclonal to PTGER3 - Cytoplasmic domain
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Monkey, Gorilla, Bat
Synthetic peptide within Human PTGER3. The exact sequence is proprietary. The synthetic peptide corresponds to 17 amino acids from the first cytoplasmic domain.
Database link: P43115
- Human breast tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab189131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 1 - 3 µg/ml.|
FunctionReceptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.
Tissue specificityExpressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- EP 3 antibody
- EP3 antibody
- EP3 I antibody
ab189131 has been referenced in 2 publications.
- Ye Y et al. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses. Endocr Connect 7:749-761 (2018). PubMed: 29700097
- Heidegger H et al. The Prostaglandin EP3 Receptor Is an Independent Negative Prognostic Factor for Cervical Cancer Patients. Int J Mol Sci 18:N/A (2017). PubMed: 28753926