Overview

  • Product name

  • Description

    Rabbit polyclonal to PTGES2/Gbf1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Recombinant fragment corresponding to Human PTGES2/Gbf1 aa 106-313.
    Database link: NP_079348

  • Positive control

    • 293T and Molt4 whole cell lysates; HepG2 and Raji lysates
  • General notes

     This product was previously labelled as PTGES2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab96189 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 42 kDa.

Target

  • Function

    Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
  • Tissue specificity

    Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
  • Pathway

    Lipid metabolism; prostaglandin biosynthesis.
  • Sequence similarities

    Belongs to the GST superfamily.
    Contains 1 glutaredoxin domain.
    Contains 1 GST C-terminal domain.
  • Cellular localization

    Golgi apparatus membrane and Cytoplasm > perinuclear region. Synthetized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.
  • Information by UniProt
  • Database links

  • Alternative names

    • C9orf15 antibody
    • FLJ14038 antibody
    • Gamma interferon activated transcriptional element binding factor 1 antibody
    • GATE binding factor 1 antibody
    • GBF 1 antibody
    • GBF1 antibody
    • Membrane associated prostaglandin E synthase 2 antibody
    • MGC11289 antibody
    • Microsomal prostaglandin E synthase 2 antibody
    • mPGES 2 antibody
    • mPGES-2 antibody
    • PGES2 antibody
    • PGES2_HUMAN antibody
    • Prostaglandin E synthase 2 antibody
    • Prostaglandin E synthase 2 truncated form antibody
    • PTGES 2 antibody
    • PTGES2 antibody
    see all

Images

  • All lanes : Anti-PTGES2/Gbf1 antibody (ab96189) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : Molt4 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 42 kDa



    10% SDS PAGE

References

This product has been referenced in:

  • Samavedi S  et al. A Three-Dimensional Chondrocyte-Macrophage Coculture System to Probe Inflammation in Experimental Osteoarthritis. Tissue Eng Part A 23:101-114 (2017). Read more (PubMed: 27736317) »
See 1 Publication for this product

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