Anti-PTHLH antibody (ab41438)
Key features and details
- Goat polyclonal to PTHLH
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PTHLH antibody
See all PTHLH primary antibodies -
Description
Goat polyclonal to PTHLH -
Host species
Goat -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Sheep, Rabbit, Cow, Cat, Dog, Pig
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Immunogen
Synthetic peptide:
AVSEHQLLHDKGKSIQDLRRRFFLHHLIA
conjugated to KLH, corresponding to amino acids 1-34 of Human PTHLH -
General notes
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Concentration information loading... -
Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Target
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Function
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
Osteostatin is a potent inhibitor of osteoclastic bone resorption. -
Tissue specificity
Ubiquitous. Also expressed in the mammary gland. -
Involvement in disease
Brachydactyly E2 -
Sequence similarities
Belongs to the parathyroid hormone family. -
Post-translational
modificationsThere are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. -
Cellular localization
Cytoplasm. Nucleus. Secreted. - Information by UniProt
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Database links
- Entrez Gene: 286767 Cow
- Entrez Gene: 403987 Dog
- Entrez Gene: 5744 Human
- Entrez Gene: 19227 Mouse
- Entrez Gene: 396951 Pig
- Entrez Gene: 24695 Rat
- Omim: 168470 Human
- SwissProt: P58073 Cow
see all -
Alternative names
- HHM antibody
- MGC14611 antibody
- Osteostatin antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab41438 has not yet been referenced specifically in any publications.