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    pthlh-antibody-ab41438.pdf

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Anti-PTHLH antibody (ab41438)

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Key features and details

  • Goat polyclonal to PTHLH
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Recombinant Human PTHLH protein (ab50228)
Secondary
Product image
Donkey Anti-Goat IgG H&L (HRP) (ab97110)

View more associated products

Overview

  • Product name

    Anti-PTHLH antibody
    See all PTHLH primary antibodies
  • Description

    Goat polyclonal to PTHLH
  • Host species

    Goat
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide:

    AVSEHQLLHDKGKSIQDLRRRFFLHHLIA

    conjugated to KLH, corresponding to amino acids 1-34 of Human PTHLH
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • Purity

    Whole antiserum
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Neuropeptides
    • Hormones
    • Signal Transduction
    • Growth Factors/Hormones
    • Hormones
    • Cell Biology
    • Cell Cycle
    • Cell differentiation
    • Neuroscience
    • Endocrine system
    • Thyroid axis
    • Stem Cells
    • Mesenchymal Stem Cells
    • Surface Molecules
    • Stem Cells
    • Mesenchymal Stem Cells
    • Osteogenesis

Associated products

  • Compatible Secondaries

    • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
    • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
  • Isotype control

    • Goat IgG, polyclonal - Isotype Control (ab37373)
  • Positive Controls

    • Recombinant Human PTHLH protein (ab50228)
  • Recombinant Protein

    • Recombinant Human PTHLH protein (ab50228)

Target

  • Function

    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.
  • Tissue specificity

    Ubiquitous. Also expressed in the mammary gland.
  • Involvement in disease

    Brachydactyly E2
  • Sequence similarities

    Belongs to the parathyroid hormone family.
  • Post-translational
    modifications

    There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
  • Cellular localization

    Cytoplasm. Nucleus. Secreted.
  • Target information above from: UniProt accession P12272 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 286767 Cow
    • Entrez Gene: 403987 Dog
    • Entrez Gene: 5744 Human
    • Entrez Gene: 19227 Mouse
    • Entrez Gene: 396951 Pig
    • Entrez Gene: 24695 Rat
    • Omim: 168470 Human
    • SwissProt: P58073 Cow
    • SwissProt: P52211 Dog
    • SwissProt: P12272 Human
    • SwissProt: P22858 Mouse
    • SwissProt: Q9GLC7 Rabbit
    • SwissProt: P13085 Rat
    • Unigene: 591159 Human
    • Unigene: 28440 Mouse
    • Unigene: 9750 Rat
    see all
  • Alternative names

    • HHM antibody
    • MGC14611 antibody
    • Osteostatin antibody
    • Parathyroid hormon like hormone isoform 2 preproprotein antibody
    • Parathyroid hormone like hormone antibody
    • Parathyroid hormone like hormone isoform 1 preproprotein antibody
    • Parathyroid hormone like protein antibody
    • Parathyroid hormone like related protein antibody
    • Parathyroid hormone related protein antibody
    • Parathyroid hormone-like protein antibody
    • Parathyroid like protein antibody
    • PLP antibody
    • PTH related protein antibody
    • PTH-rP antibody
    • PTHLH antibody
    • PTHR antibody
    • PTHR_HUMAN antibody
    • PTHrP antibody
    • PTHrP[107-139] antibody
    see all

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab41438? Please let us know so that we can cite the reference in this datasheet.

ab41438 has not yet been referenced specifically in any publications.

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