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Rabbit polyclonal to PTP1B
Mouse, Rat, Human, African green monkey
Synthetic peptide within Human PTP1B aa 16-65. The exact sequence is proprietary. (NP_002818.1).
Human kidney tissue; Extracts from COS7 cells, treated with UV 30'.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Preservative: 0.02% Sodium azide Constituents: 49% PBS, 50% Glycerol, 0.87% Sodium chloride PBS without Mg 2+ and Ca 2+.
Concentration information loading...
Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Predicted molecular weight: 50 kDa.
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
May play an important role in CKII- and p60c-src-induced signal transduction cascades.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
Contains 1 tyrosine-protein phosphatase domain.
Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
Endoplasmic reticulum membrane.
Information by UniProt
Non receptor tyrosine phosphatase 1 antibody
Protein phosphotyrosylphosphatase 1B antibody
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTP1B antibody (ab189179)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling PTP1B with ab189179 at 10 µg/ml.
Western blot - Anti-PTP1B antibody (ab189179)
All lanes : Anti-PTP1B antibody (ab189179) at 1/500 dilution Lane 1 : Extracts from COS7 cells, treated with UV 30' Lane 2 : Extracts from COS7 cells, treated with UV 30' with immunizing peptide Predicted band size: 50 kDa
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"