Overview

  • Product name

  • Description

    Rabbit polyclonal to PTP1B
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Pig, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human PTP1B (internal sequence). The exact sequence is proprietary.
    Database link: P18031

  • Positive control

    • IHC-P: Human colon carcinoma tissue. WB: Raji whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab226878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.

Target

  • Function

    May play an important role in CKII- and p60c-src-induced signal transduction cascades.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications

    Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • PTP1B antibody
    • Non receptor tyrosine phosphatase 1 antibody
    • Protein phosphotyrosylphosphatase 1B antibody
    • Protein tyrosine phosphatase 1B antibody
    • Protein tyrosine phosphatase non receptor type 1 antibody
    • Protein tyrosine phosphatase placental antibody
    • Protein-tyrosine phosphatase 1B antibody
    • PTN1_HUMAN antibody
    • PTP 1B antibody
    • PTP-1B antibody
    • PTPN 1 antibody
    • PTPN1 antibody
    • Tyrosine protein phosphatase non receptor type 1 antibody
    • Tyrosine-protein phosphatase non-receptor type 1 antibody
    see all

Images

  • Paraffin-embedded human colon carcinoma tissue stained for PTP1B using ab226878 at 1/500 dilution in immunohistochemical analysis.

  • Anti-PTP1B antibody (ab226878) at 1/500 dilution + Raji (human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

    Predicted band size: 50 kDa



    7.5% SDS PAGE gel.

References

ab226878 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab226878.
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