Key features and details
- Rabbit polyclonal to PTP4A3/PRL-R
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PTP4A3/PRL-R antibody
See all PTP4A3/PRL-R primary antibodies
DescriptionRabbit polyclonal to PTP4A3/PRL-R
Tested applicationsSuitable for: WB, ELISAmore details
Species reactivityReacts with: Human
Recombinant full length protein corresponding to Human PTP4A3/PRL-R.
Previously labelled as PTP4A3.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferConstituent: Whole serum
Concentration information loading...
Our Abpromise guarantee covers the use of ab26947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/5000. Predicted molecular weight: 19 kDa.|
FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Tissue specificityMainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain.
modificationsFarnesylated. Farnesylation is required for membrane targeting.
Cellular localizationCell membrane. Early endosome.
- Information by UniProt
- Potentially prenylated protein tyrosine phosphatase antibody
- PRL 3 antibody
- PRL R antibody
All lanes : Anti-PTP4A3/PRL-R antibody (ab26947) at 1/5000 dilution
Lane 1 : (T2.5) IPTG induction of the recombinant protein expression for 2.5 hours.
Lane 2 : (T0) before IPTG induction of the protein expression
Predicted band size: 19 kDa
Observed band size: 23.9 kDa why is the actual band size different from the predicted?
ab26947 has been referenced in 1 publication.
- Laurent C et al. High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients. Cancer Res 71:666-74 (2011). WB ; Human . PubMed: 21135111